منابع مشابه
Chronic idiopathic thrombocytopenic purpura: primum non nocere.
The vast majority of children with idiopathic thrombocytopenic purpura, dramatic though their signs may be at presentation, remit within weeks, with or perhaps despite medical attention. Such children, when referred to the Queen Elizabeth Hospital, Hackney Road by their family doctor, or appearing in the busy casualty department, have a careful history taken with particular emphasis given to th...
متن کاملChronic immune thrombocytopenic purpura. New agents.
First generation thrombopoietic growth factors (rhTPO and PEG-rHuMGDF), investigated in the early 2000s, proved effective in increasing platelet count in normal volunteers, in thrombocytopenia due to chemotherapy and also in a few cases of immune thrombocytopenic purpura (ITP). These agents did not complete their clinical development since one of them induced antibodies in the recipients that c...
متن کاملUpdate on chronic immune thrombocytopenic purpura (ITP)
Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...
متن کاملAnticoagulant therapy in chronic idiopathic thrombocytopenic purpura.
By RIai iiD J. COHEN, LEWIS H. DENNIS AND MARCEL E. CONRAD T HE PARENTERAL ADMINISTRATION of small doses of heparin to normal adults1 and to patients with arteriosclerotic heart disease2 has no measurable effect on blood platelet economy. However, larger amounts of heparin1 and therapeutic doses of bishydroxycoumarin ( Dicumarol) distinctly prolong tile survival of circulating platelets.3’4 The...
متن کاملChronic idiopathic thrombocytopenic purpura: mechanisms of pathogenesis.
The mechanism of idiopathic (autoimmune) thrombocytopenic purpura (ITP) has historically been attributed to platelet autoantibody production and the resultant platelet destruction. More recent evidence suggests a multifactorial pathogenesis. A complex picture of the immune processes involved in autoimmunity has emerged over the last decade with the identification and characterization of immunor...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1909
ISSN: 0035-9157
DOI: 10.1177/003591570900200114